Melanocortin Receptor

Melanocortin Receptor Related Products (100):

By Effects:	Inhibitors (34) Control (1) Agonists (24) Antagonists (19) Activators (2) Inducer (1)

Cat. No.	Product Name	Effect	Purity

HY-P0267

Melanotan (MT)-II	Antagonist	99.65%
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.

HY-19870

Setmelanotide	Agonist	99.93%
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

HY-107139

JNJ-10229570	Antagonist	≥98.0%
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of ¹²⁵I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC₅₀ values of 270 nM and 200 nM, respectively.

HY-P1726

MSG606	Antagonist	98.06%
MSG606 is a selective MC1R (melanocortin 1 receptor) antagonist and can be used for the research of neuroprotective effects.

HY-109114

Dersimelagon	Agonist	98.66%
Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC₅₀ values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with K_i values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation.

HY-19870C

Setmelanotide monoacetate	Agonist	99.71%
Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist that acts on human and rat MC4R with EC₅₀ values of 0.27 nM and 0.28 nM, respectively.

HY-N0637AR

(±)-Eriodictyol (Standard)
3-Chlorobenzoic acid (Standard) is the analytical standard of 3-Chlorobenzoic acid. This product is intended for research and analytical applications. 3-Chlorobenzoic acid (m-Chlorobenzoic acid) is the only carbon source for the bacterium.

HY-P991221

ALD1613	Antagonist
ALD1613 is a potent neutralizing monoclonal antibody against adrenocorticotropic hormone (ACTH). ALD1613 neutralizes ACTH-induced signaling and inhibits ACTH-induced cyclic AMP accumulation in a mouse adrenal cell line (Y1) via all five melanocortin receptors. ALD1613 significantly reduces plasma corticosterone levels in wild-type rats. ALD1613 can be used in the study of diseases associated with elevated ACTH levels.

HY-P5971

TCMCB07	Antagonist	99.67%
TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia.

HY-B1456A

Fenoprofen	Agonist	99.70%
Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.

HY-P1211

Adrenocorticotropic Hormone (ACTH) (1-39), human	Agonist	99.53%
Adrenocorticotropic Hormone (ACTH) (1-39), human is a melanocortin receptor agonist.

HY-11029

SNT-207707	Inhibitor	99.51%
SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC₅₀ of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

HY-P3561A

Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA)	Inhibitor
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake.

HY-P5971A

TCMCB07 TFA	Antagonist	99.69%
TCMCB07 TFA, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 TFA plays an important role in cachexia.

HY-P1603

ACTH (22-39)		99.79%
ACTH (22-39) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (22-39) is the 22-39 sequence of ACTH.

HY-P1558

ACTH (11-24)	Antagonist	99.65%
ACTH (11-24) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.

HY-N12267

N,N′-Diferuloylputrescine	Inhibitor
N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is a inhibitor of pigmentation with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species.

HY-118930A

MK-0493 hydrochloride	Agonist	98.76%
MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

HY-P1477

Adrenocorticotropic Hormone (ACTH) (1-39), rat	Agonist	98.73%
Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist.

HY-P4874

ACTH (7-38) (human)	Antagonist	99.92%
ACTH (7-38) (human) is the 7-38 fragment of human ACTH (1-39). human ACTH (1-39), known as a corticotropin inhibitory peptide (CIP), is an antagonist of the ACTH receptor and has no any corticosteroid activity.

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