Melanocortin Receptor

Melanocortin Receptor Related Products (106):

By Effects:	Inhibitors (36) Controls (2) Agonists (27) Antagonists (17) Activators (2) Inducer (1)

Cat. No.	Product Name	Effect	Purity

HY-P0267

Melanotan (MT)-II	Antagonist	99.97%
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.

HY-19870

Setmelanotide	Agonist	99.93%
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

HY-P5971

TCMCB07	Antagonist	99.86%
TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia. TCMCB07 has potential transport capabilities.

HY-109114

Dersimelagon	Agonist	98.66%
Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC₅₀ values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with K_i values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation.

HY-P1211

Adrenocorticotropic Hormone (ACTH) (1-39), human	Agonist	99.37%
Adrenocorticotropic Hormone (ACTH) (1-39), human is a melanocortin receptor agonist.

HY-129724A

α-MSH (11-13) acetate	Control	99.31%
α-MSH (11-13) acetate is the 11-13 amino acid (lysine-proline-valine) sequence of α-MSH (HY-P0252), which reduces fever in rabbits.

HY-P11290

MC4-NN2-0453	Agonist
MC4-NN2-0453, a α-MSH analog, is a selective MC4R agonist. MC4-NN2-0453 can be used for obesity research.

HY-P11238

Filimelnotide	Agonist
Filimelnotide is a agonist of melanocortin receptor.

HY-P3561A

Agouti-related Protein (AGRP) (83-132) Amide (human) TFA	Inhibitor
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake.

HY-11029

SNT-207707	Inhibitor	99.54%
SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC₅₀ of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

HY-B1456A

Fenoprofen	Agonist	99.70%
Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.

HY-P1477

Adrenocorticotropic Hormone (ACTH) (1-39), rat	Agonist	98.73%
Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist.

HY-P5971A

TCMCB07 TFA	Antagonist	99.69%
TCMCB07 TFA, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 TFA plays an important role in cachexia.

HY-P1603

ACTH (22-39)		99.79%
ACTH (22-39) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (22-39) is the 22-39 sequence of ACTH.

HY-118930A

MK-0493 hydrochloride	Agonist	98.76%
MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

HY-P1558

ACTH (11-24)	Antagonist	99.90%
ACTH (11-24) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.

HY-P10571

GPS1573	Antagonist	99.31%
GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC₅₀=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R.

HY-N12267

N,N′-Diferuloylputrescine	Inhibitor
N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is a inhibitor of pigmentation with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species.

HY-P4764

Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2	Agonist	99.09%
Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure.

HY-N0637A

(±)-Eriodictyol		99.0%
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities.

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